AEQUOR - Anti-Biofilm, Anti-Fouling Breakthroughs
AEQUOR  means "The Sea" in Latin.

THE DISCOVERY
Aequor's Founder, Cynthia Burzell, Ph.D., is a Medical and Marine Microbiologist who discovered natural, "green" chemicals in the ocean that control bacteria in a new way.  They inhibit the ability of Gram-negative and Gram-positive bacteria to form biofilm and remove existing biofilms.  Biofilm is an impenetrable matrix that most bacteria and some fungi form to protect themselves.  It is the cause of agro-industrial microfouling, macrofouling, and most bacterial and fungal infections

AEQUOR'S LIBRARY OF PROPRIETARY SMALL MOLECULES: 
     -- novel natural chemical compounds - new methods of use
     -- over 30 novel synthesized structural analogues of the primary novel natural chemical - structures, methods of use
     -- over 30 existing structural analogues - new methods of use
 
PRODUCT FEATURES
  • All chemical compounds remove 99.99% existing biofilm (validated by Lonza)
  • All chemicals inhibit by 99.99%the formation of biofilm by bacteria and fungi up to 48 hours (validated by USDA)
  • All are non-toxic; do not trigger resistance response
    (validated by USDA) - harmless to ecosystems and organisms at effective concentrations

     They are all different:  solubility in water, efficacy at different PH ranges and concentrations against each target
  • Some are bacteriostatic (do not kill the target)
  • Some are bactericidal/fungicidal (kill the target) = new drug candidates

PRODUCT BENEFITS

  • All are inexpensive, scale-up ready (synthesized in the lab in 3-4 steps), stable, with long shelf life in powder form
  • Can be added pre- or post-production to multiple delivery systems (washes, sprays,  gels, pastes, paints, coatings, advanced materials, etc.)

    • Require no HAZMAT protocols for shipping, use, removal, disposal
    • Some are already certified as "green" in the Directory of Green Chemicals


    PRODUCT BENEFITS
    --USE ALONE:  as inputs in end-use product formulations to replace toxic biocides (antimicrobials, disinfectants, antiseptics) and antibiotics,  particularly those that are being restricted and banned by regulators.
    --USE IN SEQUENCE/ IN COMBINATION WITH existing biocides  and antibiotics at lower doses.
    --Can be stored at ambient conditions and reconstituted when and where needed: emergencies, disasters, bio-attacks, combat, remote locations.

    BIOFILM 101
    Biofilm is everywhere.  It is found on inert, organic, and nano-surfaces -- and even on the surface of water itself.  Biofilm spreads in air and water.  For example, Legionella bacteria in shower heads became airborne and were inhaled, causing Legionnaire's Disease.

    Physical removal works to remove biofilm (scraping, sonication, heat/sterilization).  But these are short term remedies: Biofilm has been recorded on a titanium plate within 30 seconds after sterilization. Familiar example:  Dental plaque is a biofilm.  It cannot be brushed or swished away.  It has to be professionally scraped off -- repeatedly.

    Biocides, antibiotics, and the human immune system are designed to kill free-floating bacteria.  Biocides and antibiotics cannot remove biofilm at non-lethal doses.

    The overuse of biocides and antibiotics has caused environmental harm and triggered the emergence of resistant bacterial strains.

    Biofilm's impacts are widespread: 
    --MICROFOULING:  corrosion, scale, contamination on all surfaces increases costs (labor, downtime, fuel consumption, gas emissions); lowers yields and profits of cleantech and other industries (solar, wind, tidal, aquaculture, algae-biofuel, desalination, etc.)  Biofilm forms thicker and faster in outer Space.

    --MACROFOULING: attachment of eukaryotic organisms (barnacles, mussels, algae) to surfaces in contact with salt and fresh water.

    --INFECTION, DISEASE: The U.S. Centers for Disease Control associates 80% of all chronic infections; 90% of all hospital-acquired infections are associated with biofilm. 
    Where scraping is impractical, such as on delicate tissues, biofilm-caused diseases (chronic wounds, cystic fibrosis, endocarditis) are considered incurable.
        
    Every bacteria on these CDC lists is a biofilm former:
    --urgent threats (C. diff, etc.)
    --pandemic threats (cholera, Listeria, Legionella, Salmonella, E.coli, flu, pneumonia, T.B., plague, etc.)
    --biothreats (anthrax, botulism, etc.)
    --drug-resistant and multiple-drug resistant strains (MRSA, MRD-TB, etc.)

    VIDEOS:

    OVERVIEW OF AEQUOR - 1 minute:  https://www.youtube.com/watch?v=EbrPMBuAxQA
     
    Marilyn Bruno - MEDICAL APPLICATIONS AND GO TO MARKET PLAN - 2015 - 5 minutes - https://youtu.be/q_WRGRp7K2A
     
    Cynthia Burzell – ANTIFOULING - Water Summit – Lisbon – January 25, 2015 
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