AEQUOR - Anti-Biofilm, Anti-Fouling Breakthroughs
AEQUOR  means "The Sea" in Latin.

Cynthia Burzell, Ph.D., Aequor's Founder, is a Medical and Marine Microbiologist who has pioneered research in "biofilm," an impenetrable matrix that almost all marine, industrial and medical bacteria form in order to protect the underlying colony.

Dr. Burzell discovered "green" chemicals in the ocean that control bacteria in a new way.  They inhibit the ability of Gram-negative and Gram-positive bacteria to form biofilm and remove existing biofilms -- the cause of agro-industrial microfouling, macrofouling, and most bacterial infections

     -- natural chemical compounds
     -- over 30 novel synthesized structural analogues
     -- over 10 existing structural analogues (new uses)
  • All chemical compounds remove 99.99% existing biofilm (validated by Lonza)
  • All chemicals inhibit biofilm formation >99% @ 48 hours
  • Some additionally kill the target:  new drug candidates
  • All present different characteristics (solubility, PH)
  • They are all scale-up ready (synthesized in the lab in 3-4 steps)
  • Stable, long shelf life in powder form
  • Can be added pre- or post-production to multiple delivery systems (washes, sprays,  gels, pastes, paints, coatings, advanced materials, etc.)
  • Present low or no toxicity.
  • Require no HAZMAT protocols for shipping, use, removal, disposal
  • Can be certified as "green," harmless to ecosystems at effective concentrations

--USE ALONE:  as inputs in end-use product formulations to replace toxic biocides (antimicrobials, disinfectants, antiseptics, antibiotics),  particularly those that are being restricted and banned by regulators.
--USE IN SEQUENCE/ IN COMBINATION WITH existing biocides  and antibiotics at lower doses.
--Can be stored at ambient conditions and reconstituted when and where needed: emergencies, disasters, bio-attacks, combat, remote locations.

Biofilm is everywhere.  It is found on inert, organic, and nano-surfaces -- and even on the surface of water itself.  Biofilm spreads in air and water.  For example, Legionella bacteria in shower heads became airborne and were inhaled, causing Legionnaire's Disease.

Biocides, antibiotics, and the human immune system cannot penetrate or remove biofilm at non-lethal doses.

Physical removal is the traditional remedy against biofilm (scraping, sonication, heat/sterilization).
These are short term remedies: Biofilm has been recorded on a titanium plate within 30 seconds after sterilization. Familiar example:  Dental plaque is a biofilm.  It cannot be brushed or swished away.  It has to be professionally scraped off -- repeatedly.

Biocides and antibiotics can kill free-floating bacteria, but cannot penetrate or remove biofilm at non-lethal doses.  Their use/overuse has caused environmental harm and triggered the emergence of resistant bacterial strains.

Biofilm's impacts are widespread: 
--MICROFOULING:  corrosion, scale, contamination on all surfaces increases costs (labor, downtime, fuel consumption, gas emissions); lowers yields and profits of cleantech and other industries (solar, wind, tidal, aquaculture, algae-biofuel, desalination, etc.)

--MACROFOULING: attachment of eukaryotic organisms (barnacles, mussels, algae) to surfaces in contact with salt and fresh water.

--INFECTION, DISEASE: The U.S. Centers for Disease Control associates 80% of all chronic infections; 90% of all hospital-acquired infections are associated with biofilm. 
Where scraping is impractical, such as on delicate tissues, biofilm-caused diseases (chronic wounds, cystic fibrosis, endocarditis) are considered incurable.
Every bacteria on these CDC lists is a biofilm former:
--urgent   threats (C. diff, etc.)
--pandemic threats (cholera, Listeria, Legionella, Salmonella, E.coli, flu, pneumonia, T.B., etc.)
--biothreats (cholera, anthrax, plague, etc.)
--drug-resistant and multiple-drug resistant strains (MRSA, MRD-TB, etc.)


Marilyn Bruno - MEDICAL APPLICATIONS AND GO TO MARKET PLAN - 2015 - 5 minutes -
Cynthia Burzell – ANTIFOULING - Water Summit – Lisbon – January 25, 2015 -

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